Spencer Tracy as Matt Drayton

Sidney Poitier as John Prentice

Katharine Hepburn as Christina Drayton

Katharine Houghton as Joanna "Joey" Drayton

Cecil Kellaway as Monsignor Ryan

Beah Richards as Mrs. Prentice

Roy Glenn as Mr. Prentice

Isabel Sanford as Tillie

Virginia Christine as Hilary St. George

Alexandra Hay as Carhop

Barbara Randolph as Dorothy

D'Urville Martin as Frankie

Tom Heaton as Peter

Grace Gaynor as Judith

Skip Martin as Delivery Boy

John Hudkins as Cab Driver

Jacqueline Fontaine as Singer (uncredited)

Yuki Tani as Japanese Waitress (uncredited)

Garrett Cassell as Mailman (uncredited)

June Whitley Taylor as Edie (voice) (uncredited)

Natalie Core as (uncredited)

Timothy Scott as (uncredited)