Akshay Kumar as Dr. Aditya 'Adit' Shrivastav

Vidya Balan as Avni S. Chaturvedi / Manjulika

Shiney Ahuja as Siddharth Chaturvedi / Raja Vibhuti Narayan

Paresh Rawal as Batukshankar Upadhyay

Ameesha Patel as Radha Chaturvedi

Manoj Joshi as Badrinarayan 'Badri' Chaturvedi

Rajpal Yadav as Chhote Pandit / Lal Hanuman

Govardhan Asrani as Murari

Rasika Joshi as Janki Upadhyay

Vikram Gokhale as Acharya Yagyaprakash Bharti

Vineeth Radhakrishnan as Professor Sharad

Kaveri Jha as Girja Upadhyay

Tarina Patel as Nandini Upadhyay

Farida Dadi as Avni's grandmother

Jimit Trivedi as Chandu Chaturvedi