Gary Cooper as Henry Louis 'Lou' Gehrig

Teresa Wright as Eleanor Twitchell

Babe Ruth as Babe Ruth

Walter Brennan as Sam Blake

Dan Duryea as Hank Hanneman

Elsa Janssen as Christina 'Mom' Gehrig

Ludwig Stössel as Henry 'Pop' Gehrig

Virginia Gilmore as Myra Tinsley

Bill Dickey as Bill Dickey

Ernie Adams as Miller Huggins

Pierre Watkin as Mr. Twitchell

Harry Harvey as Joe McCarthy

Bob Meusel as Robert W. Meusel (as Robert W. Meusel)

Mark Koenig as Mark Koenig

Bill Stern as Bill Stern

Addison Richards as Coach

Hardie Albright as Van Tuyl

Edward Fielding as Clinic Doctor

George Lessey as Mayor of New Rochelle

Edgar Barrier as Hospital Doctor

Douglas Croft as Lou Gehrig as a Boy

Gene Collins as Billy (Age 8)

David Holt as Billy (Age 17)

Veloz as Specialty Dancer (as Veloz and Yolanda)

Yolanda as Specialty Dancer (as Veloz and Yolanda)

Ed Agresti as Barber (uncredited)

Ernie Alexander as Bellhop with Flowers (uncredited)

Hooper Atchley as Lathered Man in Barber Shop (uncredited)

Edwin August as Restaurant Patron (uncredited)

Bettye Avery as Nightclub Singer (uncredited)

Becky Bohanon as Little Girl (uncredited)

Lynton Brent as Photographer in Hospital (uncredited)

Roy Brent as Yankee Ballplayer (uncredited)

Betty Brewer as Little Girl (uncredited)

Don Brodie as Girl Show Barker (uncredited)

Charles Cane as Plumber (uncredited)

Jack Carr as Plumber (uncredited)

Burr Caruth as Village Storekeeper (uncredited)

Eddy Chandler as Motorcycle Cop #2 (uncredited)

Lane Chandler as Mark - Player in Locker Room (uncredited)

Bill Chaney as Newsboy (uncredited)

Jack Chapin as Photographer (uncredited)

Janet Chapman as Tessie (uncredited)

Spencer Charters as Mr. Larsen (uncredited)

Porter Chase as Weight Guesser (uncredited)

Dane Clark as Fraternity Boy (uncredited)

Heinie Conklin as Wallpaper Hanger (uncredited)

Hal Cooke as Man in Cab (uncredited)

Clancy Cooper as Motorcycle Cop #1 (uncredited)

John Daheim as Reporter in Hospital (uncredited)

Eva Dennison as Mrs. Worthington (uncredited)

Lester Dorr as Disappointed Fan #1 (uncredited)

Peter Du Rey as Photographer in Hospital (uncredited)

Lorna Dunn as Clinic Nurse (uncredited)

Jim Farley as Spectator (uncredited)

Frank Faylen as Yankee Third Base Coach (uncredited)

Walter Fenner as Dentist (uncredited)

Pat Flaherty as Yankee Ballplayer (uncredited)

Rosina Galli as Mrs. Fabrini (uncredited)

Vaughan Glaser as Doctor in Gehrig Home (uncredited)

Dick Gordon as Radio Listener (uncredited)

Mary Gordon as Maid (uncredited)

Herschel Graham as Spectator (uncredited)

George Guhl as Second Paper Hanger (uncredited)

Eddie Hall as Reporter in Hospital Room (uncredited)

Harry Hayden as Department Store Manager (uncredited)

Vinton Hayworth as Fraternity Boy (uncredited)

Oscar 'Dutch' Hendrian as Furniture Mover (uncredited)

John Hiestand as Announcer (uncredited)

Earle Hodgins as Bottle Game Operator (uncredited)

Fay Holderness as Spectator (uncredited)

John Ince as Man in Box Seat (uncredited)

Mitchell Ingraham as Barber (uncredited)

Charles Irwin as Carnival Batting Game Operator (uncredited)

Jack Irwin as Photographer in Hospital (uncredited)

Sheldon Jett as Sportsman at Ballgame (uncredited)

Payne B. Johnson as Boy in Ball Park (uncredited)

John Kellogg as Fraternity Boy (uncredited)

Colin Kenny as Yankee Player on Train (uncredited)

Donald Kerr as Photographer (uncredited)

Richard Kipling as Broker (uncredited)

Pat Lane as Wheel of Chance Barker (uncredited)

Larry Lawson as Barker (uncredited)

Rex Lease as Spectator (uncredited)

Theodore Lorch as Neighbor Leaning Through Window (uncredited)

Frank Lyman as Fraternity Boy (uncredited)

Wilbur Mack as Man Outside Yankee Stadium (uncredited)

Dave Manley as Mayor Fiorello LaGuardia (uncredited)

Maurice Marks as Player (uncredited)

Francisco Marán as Rathskeller Headwaiter (uncredited)

John C. McCallum as Minor Role (uncredited)

Ralph McCullough as Reporter in Hospital (uncredited)

George McDonald as Wally Pipp (uncredited)

Matt McHugh as Strength Machine Operator (uncredited)

James McNamara as Rathskeller Manager (uncredited)

Wilmuth Merkyl as Spectator (uncredited)

Howard M. Mitchell as Sportsman at Ballgame (uncredited)

Irving Mitchell as Headwaiter (uncredited)

Pat Moriarity as Policeman in 1915 (uncredited)

Tom Neal as Fraternity Boy (uncredited)

Ray Noble as Orchestra Leader (uncredited)

Patsy O'Byrne as Scrubwoman (uncredited)

George Offerman, Jr. as Freshman (uncredited)

John B. Old as Reporter (uncredited)

Garry Owen as Scorecard Vendor (uncredited)

Sarah Padden as Mrs. Roberts (uncredited)

Emory Parnell as Chicago Policeman O'Doul (uncredited)

Edward Peil Sr. as Policeman (uncredited)

Tom Quinn as Reporter in Hospital (uncredited)

Cyril Ring as Photographer (uncredited)

Henry Roquemore as Disappointed Fan #2 (uncredited)

Art Rowlands as Telephone Man (uncredited)

William Roy as Joe Fabrini (uncredited)

Rip Russell as Laddie (uncredited)

Francis Sayles as Cab Driver (uncredited)

Anita Sharp-Bolster as Sasha's Mother (uncredited)

C. Montague Shaw as Mr. Worthington (uncredited)

Jack Shea as Hammond (uncredited)

John Sheehan as First Paper Hanger (uncredited)

Jack Stewart as Ed Barrow (uncredited)

Brick Sullivan as Policeman (uncredited)

Ben Taggart as Conductor (uncredited)

Walter Tetley as Cake Delivery Boy (uncredited)

Jimmy Valentine as Sasha - Boy Playing Baseball (uncredited)

Gohr Van Vleck as Furniture Mover (uncredited)

Dorothy Vaughan as Eleanor's Landlady (uncredited)

Dorothy Vernon as Family Friend (uncredited)

Malcolm Waite as Big Strength Machine Contestant (uncredited)

James Westerfield as Spectator (uncredited)

Guy Wilkerson as Sportsman at Ballgame (uncredited)

Max Willenz as Mr. Colletti (uncredited)

Buddy Williams as Bootblack (uncredited)

Charles Williams as Little Strength Machine Contestant (uncredited)

Robert Winkler as Murphy (uncredited)

Allen Wood as Freshman (uncredited)

Mike Donovan as

Dick Gordon as Radio Listener (uncredited)

Charles Flynn as Fraternity Boy (uncredited)

Jack Gardner as

Anthony Walters as Merril (uncredited)