Sam Rockwell as Darwin the Guinea Pig (voice)

Jon Favreau as Hurley the Guinea Pig (voice)

Tracy Morgan as Blaster the Guinea Pig (voice)

Penélope Cruz as Juarez the Guinea Pig (voice)

Nicolas Cage as Speckles the Mole (voice)

Dee Bradley Baker as Mooch the Fly (voice)

Bill Nighy as Leonard Saber

Will Arnett as Kip Killian

Zach Galifianakis as Ben

Kelli Garner as Marcie

Steve Buscemi as Bucky the Hamster (voice)

Jared Lavette as Jared the Skunk (voice)

Micah Lavette as Micah the Fox (voice)

Niecy Nash-Betts as Rosalita

Loudon Wainwright III as Grandpa Goodman

Tyler Patrick Jones as Connor

Piper Mackenzie Harris as Penny

Chris Ellis as NSA Director

Gabriel Casseus as Carter

Justin Mentell as Terrell

Troy Robinson as Agent

Travis Davis as Agent

Corey Michael Eubanks as Agent

Mini Anden as Saber's Assistant

Camaron Engels as Skateboarder #1 (as Cameron Engels)

Steve Kelso as Agent

Max Favreau as Mice (voice)

James Huang as Agent

Jack Conley as Agent Trigstad