Matthew Perry as Alex Whitman

Salma Hayek Pinault as Isabel Fuentes

Jon Tenney as Jeff

Carlos Gómez as Chuy

Tomas Milian as Tomas Fuentes

Siobhan Fallon Hogan as Lanie

John Bennett Perry as Richard Whitman

Stanley DeSantis as Judd Marshall

Suzanne Snyder as Cathy Stewart

Anne Betancourt as Amalia

Jill Clayburgh as Nan Whitman

Angelina Torres as Great Grandma

Debby Shively as Donna

Mark Adair-Rios as Juan Fuentes

Annie Combs as Lisa Barnes

Shelley Morrison as Aunt Carmen

María Cellario as Aunt Yolanda

Irene Hernández as Aunt Rosa

Josh Cruze as Antonio Fuentes

Angela Lanza as Petra

Randy Sutton as Dam Policeman

Christopher Michael as Dam Policeman

Angel Valdez as Carlos

César Santana as Enrique

Garret Davis as OSHA Rep

Chris O'Neill as Priest

John Tripp as Man in Lobby

Andrew Hill Newman as Assorted Cheeses

Chris Bauer as Phil

Douglas Weston as Hank

Rupert Baca as Porter

Jan Austell as Bruce Stewart

Cydney Arther as Deane Stewart

Leslie Silva as Process Server

Maryann Plunkett as Heliport Mother

Juel Mendel as Receptionist

Eddie Powers as Elvis

Salvador Saldaña as Mariachi Singer

Robert Arevalo as Miguel Fuentes

Beth Broderick as Tracey Verna (uncredited)

Roger Anthony as Taxi Driver (uncredited)

Mark Heenehan as Wedding Official (uncredited)

Jay So as Clubgoer (uncredited)

JoAnn Bush as Night Club Patron (uncredited)