Vikram as Ramanujam 'Ambi' Iyengar / Remo / Anniyan

Sadha as Nandini Raghuram

Prakash Raj as DCP Prabhakar

Vivek as Chari Singari

Nedumudi Venu as Parthasarathy Iyengar

Nassar as Psychiatrist

Cochin Haneefa as Delinquent Car Owner

Kalabhavan Mani as House Owner

Charle as Wastrel

Shanmugarajan as Chockalingam

Saurabh Shukla as Break Company Owner

Manobala as Ticket Conductor

Shanthi Williams as Susheela, Ambi's Mother

R. Neelakantan as Ananthanarayanan

Sriranjini as Nandhini's Mother

Vatsala Rajagopal as Ambi's Grandmother

Mohan Vaidya as Krishna

Hari Prashanth as Young Ambi

Citizen Mani as A cook who works under Chockalingam

Yana Gupta as Special Appearance in "Kaadhal Yaanai" Song

Kaniha as Nandini Raghuram (Voice)

S. N. Surendar as Parthasarathy Iyengar (Voice)

Meera Krishnan as Nandhini's Mother (Voice)