Mathieu Amalric as Jean-Dominique Bauby

Emmanuelle Seigner as Céline Desmoulins

Marie-Josée Croze as Henriette Durand

Anne Consigny as Claude

Patrick Chesnais as Dr. Lepage

Niels Arestrup as Roussin

Olatz López Garmendia as Marie Lopez

Jean-Pierre Cassel as Father Lucien

Marina Hands as Joséphine

Max von Sydow as Papinou

Isaach de Bankolé as Laurent

Emma de Caunes as Empress Eugenia

Jean-Philippe Écoffey as Doctor Mercier

Gérard Watkins as Doctor Cocheton

Nicolas Le Riche as Ninjinski

Théo Sampaio as Théophile

Fiorella Campanella as Céleste

Talina Boyaci as Hortense

Anne Alvaro as Betty

Françoise Lebrun as Madame Bauby

Zinedine Soualem as Joubert

Laure de Clermont-Tonnerre as Diane

Agathe de La Fontaine as Inès

Marie Meyer as Mannequin

Ilze Bajare as Mannequin

Anna Chyzh as Mannequin

Lenny Kravitz as Himself

Michael Wincott as Fashion Photographer