Don Cheadle as Paul Rusesabagina

Sophie Okonedo as Tatiana Rusesabagina

Nick Nolte as Colonel Oliver

Fana Mokoena as General Bizimungu

Desmond Dube as Dube

Hakeem Kae-Kazim as George Rutaganda

Tony Kgoroge as Gregoire

Cara Seymour as Pat Archer

David O'Hara as David

Joaquin Phoenix as Jack Daglish

Mosa Kaiser as Elys Rusesabagina

Mathabo Pieterson as Diane Rusesabagina

Ofentse Modiselle as Roger Rusesabagina

Xolani Mali as Policeman

Rosie Motene as Receptionist

Neil McCarthy as Jean Jacques

Mabutho 'Kid' Sithole as Head Chef

Jeremiah Ndlovu as Old Guard

Lebo Mashile as Odette

Antonio David Lyons as Thomas Mirama

Leleti Khumalo as Fedens

Kgomotso Seitshohlo as Anais

Lerato Mokgotho as Carina

Lennox Mathabathe as Peter

Mothusi Magano as Benedict

Noxolo Maqashalala as Chloe (Prostitute)

Thulani Nyembe as Jean Baptiste

Simo Mogwaza as Hutu Captain

Mirriam Ngomani as Gregoire's Girlfriend

Harriet Lenabe as Alice the Waitress

Roberto Citran as Priest

Mduduzi Mabaso as Hutu Lieutenant

Sonni Chidiebere as Militiaman

Thomas Kariuki Matheri as Xavier

Sibusiso Mhlongo as Militiaman

Ashleigh Tobias as Medic

Jean Reno as Sabena Airlines President, Mr. Tillens (uncredited)