Adam Sandler as George Simmons

Seth Rogen as Ira Wright

Leslie Mann as Laura

Eric Bana as Clarke

Jonah Hill as Leo Koenig

Jason Schwartzman as Mark Taylor Jackson

Aubrey Plaza as Daisy Danby

RZA as Chuck

Aziz Ansari as Randy

Maude Apatow as Mable

Iris Apatow as Ingrid

Torsten Voges as Dr. Lars

Allan Wasserman as Dr. Stevens

Rod Man as Rod Man

Wayne Federman as Comedy & Magic Manager

Mike O'Connell as MySpace Escort

James Taylor as James Taylor

Nicole Parker as Dawn

Nydia McFadden as Mandy

Andy Dick as Andy Dick

Charles Fleischer as Charles Fleischer

Nicol Paone as George's Sister

George Coe as George's Dad

Budd Friedman as Budd Friedman

Monty Hoffman as Monty Hoffman

Carol Leifer as Carol Leifer

Paul Reiser as Paul Reiser

Mark Schiff as Mark Schiff

George Wallace as George Wallace

Norm Macdonald as Norm Macdonald

Dave Attell as Dave Attell

Sarah Silverman as Sarah Silverman

Bryan Batt as George's Agent

Maggie Siff as Rachel

Eminem as Eminem

Ray Romano as Ray Romano

Jon Brion as Jon Brion

Sebastian Steinberg as Sebastian Steinberg

James Gadson as James Gadson

Arshad Aslam as Yo Teach Cast Member

Bo Burnham as Yo Teach Cast Member

Miki Ishikawa as Yo Teach Cast Member

Kenny Copeland Jr. as Yo Teach Cast Member

Calvin Sykes as Yo Teach Cast Member

Ca'Shawn Sims as Yo Teach Cast Member

Mandi Kreisher as Yo Teach Cast Member

Phillip Andre Botello as Yo Teach Cast Member

Carla Gallo as Miss Pruitt on Yo Teach

Ernest Lee Thomas as Yo Teach Principal

Tonita Castro as Bonita

Carlos Andrade as Gardener

Steve Bannos as Deli Manager

Justin Long as Re-Do Guy

Lucas Astrom as College Guy with Camera

Tyler Spindel as College Guy with Camera

Deamor Yi as 8-Year-Old Girl Fan

Elaine Kao as Mom with Camera

King Kedar as Family with Camera

Andre Butler Jr. as Family with Camera

Tanya Acker as Family with Camera

Jarrett Grode as Magician

Qiana Chase as Chuck's Wife

Tom Anderson as Tom Anderson

John Hartmann as Private Jet Pilot

Dave Rath as San Francisco Theatre Manager

Dan Harmon as Paparazzi at Medical Center

Brandon Cournoyer as Paparazzi at Medical Center

Kyle Kinane as Paparazzi at Medical Center

Mark Cohen as Emcee at Improv

Denise Meyerson as Deli Customer

Joanie Marx as Deli Customer

Adam J. Bernstein as Hot Dog-Eating Champion's Son

Da'Vone McDonald as Hot Dog-Eating Co-Star

Orny Adams as Orny Adams

Al Lubel as Al Lubel

Jerry Minor as Jerry Minor

Eleanor Zee as George's Mom

Ben Meyerson as George's Brother-In-Law

Sammy Jack as George's Young Nephew

Kim Taylor as Kim Taylor

Andrea Zonn as Andrea Zonn

Kate Markowitz as Kate Markowitz

Arnold McCuller as Arnold McCuller

Larry Goldings as Larry Goldings

Luis Conte as Luis Conte

Russ Kunkel as Russ Kunkel

Brad Grunberg as Comedy & Magic Club Audience

Brian Lally as Comedy & Magic Club Audience

Jimmy Johnson as Jimmy Johnson

Janeane Garofalo as Friend in video (archive footage) (uncredited)

Ben Stiller as Friend in video (archive footage) (uncredited)

Judd Apatow as Friend in video (voice) (archive footage) (uncredited)