Stephen Mailer as Gabriel Higgs

Grahame Wood as Lab Partner

Kristy Swanson as Kirby Watts

Daniel R. Gerson as Ross

Stan Brown as Professor

Sean Bridgers as Dumpster Hunter

Len Cariou as Dr. Lionel Higgs / Dr. Ezekial Higgs

Christine Baranski as Mrs. Margaret 'Maggie' Higgs

Dorothy Recasner Brown as Proctor

Dave Chappelle as Ron

Andrew McCarthy as Rupert Grimm

George Lee as Dr. Peters

Christina Keefe as Rachel

Roy Lind as Dean Stiller

Laura Cathey as Jubilant Student

Kate Finlayson as Helen

Joanne Pankow as Nurse

Pat Lavelle as Receptionist

Matthew Perry as Randall Burns

Blake Lindsley as Tina

Colleen Doherty as Coed

Nealy Glenn as Tense Student

Calista Flockhart as Amanda Morel

Claire Whitworth as Jody

Andrew Lauren as Fraternity Brother

Hedgie Bartol as Fraternity Brother

Jackson Walker as Fraternity Brother

Spiro Malas as Mr. Grimm

Rick Andosca as Cop

Angela Jones as Librarian

Bahni Turpin as Valerie Bookbinder

Robert Longstreet as Man in Library

Jason Jenks as Hacker

David Holland as Officer Denby

Avram Ludwig as Officer

Gary Gennerich as Sergeant

Arthur L. Liman as Anatomy Professor

Mary Helen Sifford as Student (Uncredited)

Zed Starkovich as Student (Uncredited)

Thomas Downey as Frisbee Stud (uncredited)