Kevin Bacon as Balto (voice)

Bob Hoskins as Boris the Goose (voice)

Bridget Fonda as Jenna (voice)

Jim Cummings as Steele the Sled Dog (voice)

Phil Collins as Muk and Luk (voice)

Juliette Brewer as Young Rosy (voice)

Jack Angel as Nikki (voice)

Danny Mann as Kaltag (voice)

Robbie Rist as Star (voice)

Sandra Dickinson as Dixie / Sylvie (voice)

Frank Welker as Grizzly Bear (voice)

Miriam Margolyes as Grandma Rosy

Lola Bates-Campbell as Rosie's granddaughter

Donald Sinden as Doc (voice)

Garrick Hagon as Telegraph Operator (voice)

William Roberts as Rosy's Father (voice)

Big Al as Town Dog (voice)