William Hurt as Prof. John Robinson

Matt LeBlanc as Maj. Don West

Mimi Rogers as Dr. Maureen Robinson

Heather Graham as Dr. Judy Robinson

Gary Oldman as Dr. Zachary Smith

Lacey Chabert as Penny Robinson

Jack Johnson as Will Robinson

Jared Harris as Older Will Robinson

Mark Goddard as General

Lennie James as Jeb Walker

Marta Kristen as Reporter #1

June Lockhart as Principal Cartwright

Adam Sims as Lab Technician

Angela Cartwright as Reporter #2

John Sharian as Noah Freeman

Abigail Canton as Annie Tech

Richard Saperstein as Global Sedition attack pilot

Dick Tufeld as Rambler-Crane series Robot (voice)

Gary A. Hecker as Blarp (voice)

Edward Fox as Businessman

Kamay Lau as Space Cadet Reporter