Ross Bagdasarian, Jr. as David Seville / Alvin Seville / Simon Seville (voice)

Janice Karman as Theodore / Brittany / Jeanette / Eleanor (voice)

Dody Goodman as Miss Rebecca Miller (voice)

Susan Tyrrell as Claudia Furschtien (voice)

Anthony De Longis as Klaus Furschtien (voice)

Frank Welker as Sophie / Native Chief / Baby Penguin / Additional Voices (voice)

Nancy Cartwright as Arabian Prince (voice)

Philip L. Clarke as Additional Voices (voice)

Ken Sansom as Inspector Jamal (voice)

George Poulos as Additional Voices (voice)

Charlie Adler as Additional Voices (voice)

Patrick Pinney as Additional Voices (voice)

Jack Angel as Additional Voices (voice; uncredited)

Mel Blanc as Additional Voices (voice; uncredited)

Laura Summer as Additional Voices (voice; uncredited)