Andy Griffith as Larry 'Lonesome' Rhodes

Patricia Neal as Marcia Jeffries

Anthony Franciosa as Joey DePalma

Walter Matthau as Mel Miller

Lee Remick as Betty Lou Fleckum

Percy Waram as General Haynesworth

Paul McGrath as Macey

Rod Brasfield as Beanie

Marshall Neilan as Senator Worthington Fuller

Alexander Kirkland as Jim Collier

Charles Irving as Mr. Luffler

Howard Smith as J.B. Jeffries

Kay Medford as First Mrs. Rhodes

Big Jeff Bess as Sheriff Big Jeff Bess

Henry Sharp as Abe Steiner

R.G. Armstrong as Teleprompter Operator (uncredited)

Lois Nettleton as Mr. Macey's Nurse (uncredited)

Diana Sands as Homeless Woman (uncredited)

Rip Torn as Barry Mills (uncredited)

Beverly Bentley as Page Girl (uncredited)

John Bliss as Barefoot Baritone (uncredited)

Noah Keen as TV Director (uncredited)