Pam Grier as Coffy

Robert DoQui as King George

Sid Haig as Omar

Booker Bradshaw as Howard Brunswick

William Elliott as Carter Brown

Allan Arbus as Arturo Vitroni

Linda Haynes as Meg

Barry Cahill as McHenry

Lee de Broux as Nick

Ruben Moreno as Ramos

Lisa Farringer as Jeri

Carol Locatell as Priscilla

John Perak as Aleva

Mwako Cumbuka as Grover

Morris Buchanan as Sugarman

Peaches Jones as Julia

Jan-Minika Hughes as Billie

Leslie McRay as Cindy

Ray Young as Jake

Bob Minor as Studs

Jeff Burton as Dr. Brannan

Wally Strauss as Doctor

Dick O'Shea as Doctor #2

Kim Williams as Nurse #1

Ellen Blake as Nurse #2

Lee Terry as Nurse #3

Gail Davis as Bricke Redd

Lyman Ward as Orderly

Don Newsome as Attendant

Karen Williams as LuBelle Coffin

Bobby Johnson as Floyd

Ron Gans as Stranger

Nat Jones as Stoned Boy

Dea St. Lamont as Harriet

Bebe Louie as Helen

Jason Laskay as Ron

Walter Beakel as Director

Eugene Jackson as Man at Rally (uncredited)

Calvin Brown as Party Guest (uncredited)

Eumenio Blanco as Hospital Visitor (uncredited)

Gwen Farrell as Waitress in Club (uncredited)

Edward Coch Jr. as Club Patron (uncredited)

Hans Moebus as Club Patron (uncredited)

Cosmo Sardo as Club Patron (uncredited)