Burt Lancaster as Marshal Wyatt Earp

Kirk Douglas as Dr. John 'Doc' Holliday

Jo Van Fleet as Kate Fisher

Rhonda Fleming as Laura Denbow

John Ireland as Johnny Ringo

Lyle Bettger as Ike Clanton

Frank Faylen as Sheriff Cotton Wilson

Earl Holliman as Deputy Sheriff Charles 'Charlie' Bassett

Ted de Corsia as Shanghai Pierce

Dennis Hopper as Billy Clanton

Whit Bissell as 'Tombstone Epitaph' Editor John P. Clum

George Mathews as Griffin Saloonkeeper John Shanssey

John Hudson as Virgil Earp

DeForest Kelley as Morgan Earp

Martin Milner as James 'Jimmy' Earp

Kenneth Tobey as Bat Masterson

Lee Van Cleef as Ed Bailey

Joan Camden as Betty Earp

Olive Carey as Mrs. Clanton

Brian G. Hutton as Rick

Nelson Leigh as Mayor Kelly

Jack Elam as Tom McLowery

Don Castle as Drunk Cowboy in Longbranch Saloon

Franklyn Farnum as Barfly (uncredited)

Charles Herbert as Tommy Earp (uncredited)

Kenner G. Kemp as Croupier (uncredited)

Colin Kenny as Barfly (uncredited)

Bert Stevens as Party Guest (uncredited)

Arthur Tovey as Barfly (uncredited)

Leslie Sketchley as Barfly (uncredited)

John Benson as Stage Driver (uncredited)

Frank Hagney as Bartender (uncredited)

Richard Reeves as Pierce's Foreman (uncredited)

Charles Fogel as Barfly (uncredited)

Raoul Freeman as Party Guest (uncredited)

Stuart Hall as Party Guest (uncredited)