Michael Cera as Nick Twisp / François Dillinger

Portia Doubleday as Sheeni Saunders

Jean Smart as Estelle Twisp

M. Emmet Walsh as Mr. Saunders

Steve Buscemi as George Twisp

Adhir Kalyan as Vijay Joshi

Fred Willard as Mr. Ferguson

Ray Liotta as Lance Wescott

Zach Galifianakis as Jerry

Erik Knudsen as Lefty

Ari Graynor as Lacey

Justin Long as Paul Saunders

Rooney Mara as Taggarty

Jade Fusco as Bernice Lynch

Lise Lacasse as Matron

Mary Kay Place as Mrs. Saunders

Jonathan B. Wright as Trent

Michael Collins as Old Man

Gregory F. Anderson as Sailor #1

Connell Brown as Sailor #2

Randy Godwin as Officer #1

Tony Fanning as Officer #2

Francine Roussel as Headmistress

Chuy Chávez as Illegal Immigrant #1

Miguel Arteta as Illegal Immigrant #2

Bruce Lawson as Officer A. Fanning

Sudhi Rajagopal as Officer T. Cahill

Roz Music as Store Clerk

Christa B. Allen as Teenage Girl

Trevor Duke-Moretz as Jock Guy

JoAnn Fregalette Jansen as Sheeni Consultant