Charlie Cox as Tristan Thorn

Claire Danes as Yvaine

Michelle Pfeiffer as Lamia

Mark Strong as Septimus

Jason Flemyng as Primus

Robert De Niro as Captain Shakespeare

Sienna Miller as Victoria

Sarah Alexander as Empusa

Joanna Scanlan as Mormo

Melanie Hill as Ditchwater Sal

Mark Heap as Tertius

Rupert Everett as Secundus

David Walliams as Sextus

Adam Buxton as Quintus

Julian Rhind-Tutt as Quartus

Peter O'Toole as King

Kate Magowan as Una / Slave Girl

Jake Curran as Bernard

David Kelly as Guard

Nathaniel Parker as Dunstan Thorn

Ricky Gervais as Ferdy the Fence

Dexter Fletcher as Skinny Pirate

Henry Cavill as Humphrey

Mark Williams as Billy

Olivia Grant as Girl Bernard

Ian McKellen as Narrator (voice)

Ben Barnes as Young Dunstan Thorn

Bimbo Hart as Young Scientist

Alastair MacIntosh as Victorian Academic

Darby Hawker as Grumpy Customer

Frank Ellis as Mr. Monday

Struan Rodger as Bishop

George Innes as Soothsayer

Grant Burgin as Lackey

Eliot Sumner as Yvaine's Sister

Terry Murphy as Old Pirate

Geoff Bell as Receptionist

Mark Burns as New Bishop

Rab Affleck as Pirate

Carlos Besse Peres as Pirate

Elwin 'Chopper' David as Pirate

Adam Fogerty as Pirate

Jordan Long as Pirate

Spencer Wilding as Pirate

Philip Harvey as Bishop's Assistant