Charlie Cox as Tristan Thorn

Claire Danes as Yvaine

Sienna Miller as Victoria

Ricky Gervais as Ferdy the Fence

Jason Flemyng as Primus

Mark Strong as Septimus

Rupert Everett as Secundus

Peter O'Toole as King

Michelle Pfeiffer as Lamia

Robert De Niro as Captain Shakespeare

Sarah Alexander as Empusa

Melanie Hill as Ditchwater Sal

Joanna Scanlan as Mormo

Kate Magowan as Una / Slave Girl

David Kelly as Guard

Nathaniel Parker as Dunstan Thorn

Dexter Fletcher as Skinny Pirate

Henry Cavill as Humphrey

David Walliams as Sextus

Mark Heap as Tertius

Mark Williams as Billy

Ian McKellen as Narrator (voice)

Adam Buxton as Quintus

Bimbo Hart as Young Scientist

Alastair MacIntosh as Victorian Academic

Ben Barnes as Young Dunstan Thorn

Darby Hawker as Grumpy Customer

Frank Ellis as Mr. Monday

Struan Rodger as Bishop

Julian Rhind-Tutt as Quartus

George Innes as Soothsayer

Jake Curran as Bernard

Grant Burgin as Lackey

Olivia Grant as Girl Bernard

Eliot Sumner as Yvaine's Sister

Terry Murphy as Old Pirate

Geoff Bell as Receptionist

Mark Burns as New Bishop

Rab Affleck as Pirate

Carlos Besse Peres as Pirate

Elwin 'Chopper' David as Pirate

Adam Fogerty as Pirate

Jordan Long as Pirate

Spencer Wilding as Pirate