Dan Aykroyd as Clifford Skridlow / Doctor Detroit

Howard Hesseman as Smooth Walker

Donna Dixon as Monica McNeil

Lydia Lei as Jasmine Wu

T.K. Carter as Diavolo Washington

Lynn Whitfield as Thelma Cleland

Fran Drescher as Karen Blittstein

Kate Murtagh as Mom

Nan Martin as Margaret Skridlow

George Furth as Arthur Skridlow

Peter Elbling as Guptor

John A. Maloney as Commodore

Pershing P. Anderson as Stretch

William Munchow as Professor Artel

Ed Meekin as Professor Durant

Hank Salas as Johnny

Rudolph Kovar as Carson

Peter Aykroyd as Mr. Frankman

Glenne Headly as Miss Debbylike

Annabel Armour as Airline Clerk

Robert Cornthwaite as Professor Blount

Thomas O. Erhart Jr. as Dean Swift

Parley Baer as Judge

Oliver Clark as Shaky Alcoholic Lawyer

Ben Kronen as Bailiff

Lance Kinsey as Street Dude

Andrew Duggan as Harmon Rousehorn

Victoria Brown as Mrs. Fulsom

Blackie Dammett as Eddie Four Eyes

James Brown as Bandleader

Alan Ruck as Student

Marilyn Corwin as Dancer (uncredited)

Sue Bowser as Dream Girl

Derrick Brice as Players Ball Dancer

Steven Williams as Junior Sweet