James Arnold Taylor as Ratchet (voice)

David Kaye as Clank (voice)

Jim Ward as Captain Qwark (voice)

Paul Giamatti as Chairman Drek (voice)

Armin Shimerman as Dr. Nefarious (voice)

Rosario Dawson as Elaris (voice)

Bella Thorne as Cora Veralux (voice)

Vincent Tong as Brax / Solana Trooper (voice)

Andrew Cownden as Zed / Blarg (voice)

Sylvester Stallone as Victor Von Ion (voice)

John Goodman as Grimroth (voice)

Lee Tockar as Mr. Micron (voice)

Brian Dobson as Dallas Wannamaker / Announcer / Drek Computer (voice)

Tabitha St. Germain as Juanita Alvaro (voice)

Brad Swaile as Ollie / Super Fan (voice)

Brian Drummond as Inspectobot / Warbot / Zurkons (voice)

Cole Howard as Blarg (voice)

Ian James Corlett as Blarg (voice)

Alessandro Juliani as Solana Trooper (voice)

Rebecca Shoichet as Stanley's Mom / Ship Computer (voice)

Don Briggs as Starship Commander (voice)