Brendan Fraser as Stu Miley

Bridget Fonda as Dr. Julie McElroy

John Turturro as Monkeybone (voice)

Chris Kattan as Organ Donor Stu

Giancarlo Esposito as Hypnos

Rose McGowan as Miss Kitty

Dave Foley as Herb

Megan Mullally as Kimmy Miley

Bob Odenkirk as Head Surgeon

Whoopi Goldberg as Death

Pat Kilbane as Burger God Representative

Lisa Zane as Medusa

Sandra Thigpen as Alice

Wayne Wilderson as Hutch

Amy Higgins as Clarissa

Alan Gelfant as Dr. Edelstein

Kristin Norton as Nurse

Chris Hogan as Bill, Bazoom Toy Representative

Lucy Butler as Guest

John Sylvain as Ambulance Driver

Lou Romano as Cop / Psycharist

Leon Laderach as Surgeon in Nightmare

Scott Rogers as Surgeon

Cris Thomas-Palomino as Surgeon

Tony Panterra as Surgeon

Ted Rooney as Grim Reaper (voice)

Christopher Franciosa as Reaper Who Takes Lulu

Mary Stein as Lulu

Fred Pierce as Reaper in Death's Office

Harper Roisman as Earl Biegler

Kristopher Logan as Patron

Scott Workman as Arnold the Super Reaper

Shawnee Free Jones as Lizzie Borden

Ilia Volok as Rasputin

Edgar Allan Poe IV as Edgar Allan Poe

Claudette Mink as Typhoid Mary

Jon Bruno as Man in the Dungeon / Stephen King

Owen Masterson as Jack the Ripper

Jen Sung as Attila the Hun

Tracy Zahoryin as Model

Sunshine Deia Tutt as Model

Jo Haugen Gash as Model

Lindsay Bryan as Model

Brooke Boisse as Model

Meron Abebe as Model

Mie Kringelbach as Model

Rex Reddick as Museum Guard / Tuxedo Guard

Sybil Azur as Museum Dancer

Anne Fletcher as Museum Dancer

Diane Mizota as Museum Dancer

Etty Lau as All-Girl Band Sax Player

LaTonya Holmes as All-Girl Band Percussionist

Lesli Jean Matta as All-Girl Band Drummer

Dawn Solér as All-Girl Band Member

Miko Watanbe as All-Girl Band Member

Frankie Pine as All-Girl Band Member

Anne King as All-Girl Band Member

Rachen Assapiomonwait as Korean Father

Veena Bidasha as Statue Woman

Michael Anthony Jackson as Bug Man

Doug Jones as Yeti

Arturo Gil as Rat Guard

Jody St. Michael as Centaur

Brian Steele as Jumbo the Elephant God

Leif Tilden as Cyclops

Tom Fisher as Community Service Cigarette Sweeper

Joseph S. Griffo as BBQ Pig

Kim Timbers-Patteri as Wasp Woman

Lisa Ebeyer as Betty the Bovine

Mark Viniello as Assbackward

Nathan Stein as Sea Monster

Ed Holmes as Buffalo Kuchina

Erica Gudis as Party Babe Hybrid #1

Melinda Miamor as Party Babe Hybrid #2

Caroline A. Rice as Party Babe Hybrid #3

Joe Ranft as Streetsquash Rabbit (voice)

Bruce Lanoil as Streetsquash Raccoon (voice)

Debi Durst as Streetsquash Snake (voice)

Phil Brotherton as Subramansa (voice)

Roger L. Jackson as Arnold the Super Reaper (voice)

Jym Dingler as Community Service Cigarette Sweeper (voice)

Leslie Hedger as Assbackward (voice)

Toby Gleason as Buffalo Kachina (voice)

Allan Trautman as BBQ Pig (voice)

Mike Mitchell as Miss Hudiapp (voice)

Randall Bosley as Fred

Brendan Burns as Detective #1

Robert 'Duckie' Carpenter as Record Store Owner / Coma Victim

Thomas Haden Church as Death's Assistant

Jamie Donovan as Reporter #1

Roger Ferreira as Visitor

Wendy Fowler as Beautiful Fan

Paul Guiles as Reporter #2

Harry Jay Knowles as Lucky

Jason Kravits as Guest

Skyler Marshall as Janitor

George Meyers as Bazoom Toy Rep

Michelle Shaffer as Woman with Bat

Tom Tangen as Burger God Representative