Bill Murray as Vincent MacKenna

Melissa McCarthy as Maggie Bronstein

Jaeden Martell as Oliver Bronstein

Naomi Watts as Daka Parimova

Chris O'Dowd as Brother Geraghty

Terrence Howard as Zucko

Scott Adsit as David

Lenny Venito as Coach Mitchell

Nate Corddry as Terry

Dario Barosso as Robert Ocinski

Kimberly Quinn as Ana

Donna Mitchell as Sandy

Ann Dowd as Shirley

Reg E. Cathey as Gus

Deirdre O'Connell as Linda

Ray Iannicelli as Roger

Greta Lee as Teller #23

Maria Elena Ramirez as Amelda

Ron McLarty as Principal O'Brien

Niles Fitch as Brooklyn

Emma Fisher as Bridgette

David Iacono as Jeremiah

Alexandra Fong as Rachele

Sade Demorcy as Keesha

Gabe Hernandez as Latin Mover

Elliot Santiago as Latin Driver

Melanie Nicholls-King as Hospital Supervisor

Portia as Ultrasound Tech

Maria-Christina Oliveras as Medical Receptionist

James Andrew O'Connor as Antwan, Zucko's Partner

Brian Berrebbi as Process Server

Brenda Wehle as Judge Reynolds

Frank Wood as Maggie's Attorney

Orlagh Cassidy as Speech Therapist

Larry Gray as Belmont Teller

Joann Lamneck as Belmont Bartender

Kerry Flanagan as CT Scan Nurse

Katharina Damm as Starlet, the Dancer

Jeff Bowser as Physical Therapist

Amber Clayton as Amber, the Waitress

Fred Evanko as David's Attorney

Ron Bush as Buy Buy Baby Salesman

Tim Wilson as Priest at Assembly

J. Elaine Marcos as Nurse

David Filippi as Cab Driver

Tim Durkin as Belmont Race Caller (voice)

Richard Ford as Nature Program Narrator (voice)

Addison Rose Melfi as Girl in Class

Josh Elliott Pickel as Student (uncredited)

Alyssa Ruland as Student (uncredited)

Brett Kaminsky as School bully