Vince Vaughn as Dan Trunkman

Dave Franco as Mike Pancake

Sienna Miller as Chuck Portnoy

Tom Wilkinson as Timothy McWinters

James Marsden as Jim Spinch

June Diane Raphael as Susan Trunkman

Nick Frost as Bill Whilmsley

Ella Anderson as Bess Trunkman

Anastasia Mousis Sanidopoulos as Farm Goer

Melissa McMeekin as National Rental Clerk

David C. Bunners as Pedestrian

Frowin Wolter as Hostel Kid

Britton Sear as Paul Trunkman

Kasia Malinowska as Craigslist Maid

Michael Krabbe as Dandlin Desk Clerk

Uwe Ochsenknecht as Maarten Daaervk

Rainer Reiners as Tourist

John Franchi as Professional Business Traveler

Jil Funke as Pretty German Girl

Bonita Friedericy as Helen (as Bonita Fri Edericy)

Clement von Franckenstein as Armand (uncredited)

Jeffrey Corazzini as Businessman (uncredited)

Susan Garfield as Business Woman (uncredited)

David Brückner as Band Singer on Stage (uncredited)

Noelle Trudeau as Topless Pillow Girl (uncredited)

Austin J. Ryan as Classmate (uncredited)