Ian Bagg as Ian

Greg Baker as Francis "LC" O'Reilly

Bernadette Birkett as Mama O'Reilly

Connie Britton as Connie

Carla Gugino as Carla

Michael Cotter as Michael

Mark Devine as Bud O'Reilly

Timothy Dowling as Rupert Cook

Lauren Graham as Dr. Sue Pegasus

Staci Greason as Self

Chris Hardwick as Milos

Jennifer Jostyn as Sunshine Hilton

Cynthia Koury as Indonesia

Lance Krall as Larry Dibner

Leila Leigh as Gloria Lohman

Ron Livingston as Ron

Mace Lombard as Johnny Dragone

Mack-b as Rapper

Robin McDonald as Botox party guest

Scott Mitchell Nelson as Austin

Sam Pancake as Tracy Neustadt

Tom Papa as Fritz Goldfarb

Jonathan Silverman as Jonny

Hrach Titizian as Hrach

Daniel Weiss as Blind date

George Wendt as George

Rainn Wilson as Dr. Watson Newmark

Owen Williams as Andrew Banyon