Chris Massoglia as Darren Shan

John C. Reilly as Larten Crepsley

Josh Hutcherson as Steve

Patrick Fugit as Evra the Snake Boy

Salma Hayek Pinault as Madame Truska

Jessica Carlson as Rebecca

Michael Cerveris as Mr. Tiny

Ray Stevenson as Murlaugh

Morgan Saylor as Annie

Don McManus as Mr. Shan

Ken Watanabe as Mr. Tall

Orlando Jones as Alexander Ribs

Frankie Faison as Rhamus Twobellies

Willem Dafoe as Gavner Purl

Kristen Schaal as Gertha Teeth

Patrick Breen as Mr. Kersey

Tom Woodruff Jr. as Wolfman

Jane Krakowski as Corma Limbs

Drew Rin Varick as Loaf Head

Colleen Camp as Mrs. Shan

Lo Graham as Student in Hallway and Classroom

Beau Holden as Trucker

Trey Burvant as Singing Dad

Daniel Newman as Pete

Brandon Molale as Vampaneze (uncredited)

Gino Galento as Madame Truska's Man (uncredited)

Sam Medina as Madame Truska's Man (uncredited)

Cody Klop as Voice