Eric Bana as Henry DeTamble

Rachel McAdams as Clare Abshire

Michelle Nolden as Annette DeTamble

Arliss Howard as Richard DeTamble

Ron Livingston as Gomez

Stephen Tobolowsky as Dr. Kendrick

Brian Bisson as Mark Abshire

Maggie Castle as Alicia Abshire

Brooklynn Proulx as Clare at Six and Eight

James Lafazanos as Jeremy (Gallery Owner)

Dan Duran as Lottery Announcer

Jan Caruana as Dr. Osman's Nurse

Jean Yoon as Dr. Montague

Duane Murray as Resident Doctor

Philip Craig as Philip Abshire

Fiona Reid as Lucille Abshire

Alex Ferris as Henry at Six

Katherine Trowell as Hospital Receptionist

Bart Bedford as Library Researcher

Esther Jun as Waitress

Esther Jun as Chicago Police #1

Craig Snoyer as Chicago Police #2

Carly Street as Librarian

Romyen Tangsubutra as Thai Waiter

Mario Tufino as Barber

Shawn Storer as Moving Man

David Talbot as Pastor

Kenner Ames as TV Sales Person

Alison MacLeod as Realtor

Hailey McCann as Alba at Nine and Ten

Donald Carrier as Dr. Osman

Tatum McCann as Alba at Four and Five

Jon Bruno as Chicago Radio Show Host

Scott Menville as Voice Over (Voice)

Paul Francis as Hunting Buddy

Matt Birman as Chicago Police #1