Missi Pyle as Lucy

Melissa McCarthy as Becky

Josh Hopkins as George

Octavia Spencer as Mary

Jack Noseworthy as Trevor

Larry Sullivan as Austin

Allison Janney as Suzanna

Phill Lewis as Raye

William Sanderson as Sam

Allison Mackie as Bitter Flight Attendant

Amy Landers as Puffy Paint Flight Attendant

Ben Falcone as Coach Merryweather

Tate Taylor as George's Boyfriend

Philip Littell as Richard

Stacy Yutuc as Flirty Flight Attendant

Drew Matthews as Boy

Sean Daly as Park Ranger

Brutus as Bear

Wyatt Earp as Airport Announcer (voice)