Jeremy Renner as Gary Webb

Mary Elizabeth Winstead as Anna Simons

Michael Sheen as Fred Weil

Ray Liotta as John Cullen

Robert Patrick as Ronny Quail

Andy García as Norwin Meneses

Paz Vega as Coral Baca

Michael Kenneth Williams as Ricky Ross

Rosemarie DeWitt as Sue Webb

Tim Blake Nelson as Alan Fenster

Barry Pepper as Russell Dodson

Oliver Platt as Jerry Ceppos

Richard Schiff as Richard Zuckerman

Jena Sims as Quail's Girlfriend

Joshua Close as Rich Kline

Yul Vazquez as Danilo Blandon

Lucas Hedges as Ian Webb

Matt Lintz as Eric Webb

Gil Bellows as DEA Agent Miller

Steve Coulter as Anonymous Agent

Dan Futterman as Leo Wolinsky

Susan Walters as Los Angeles Times Editor

David de Vries as Washington Post Editor

David Lee Garver as Doug Farah

Rhoda Griffis as Female Anchor

Jen Harper as Ricky Ross Trial Judge

David Alessi as DEA Agent (uncredited)

Grace Baine as Reporter Washington Post (uncredited)

Shaira Barton as DC Business Woman (uncredited)

Nancy Reagan as Self (archive footage) (uncredited)

Parker Douglas as Christine Webb

James Lewis as Jaguar Driver