David Byrne as Narrator / Lip-Syncher

John Goodman as Louis Fyne

Annie McEnroe as Kay Culver

Jo Harvey Allen as The Lying Woman

Spalding Gray as Earl Culver

Alix Elias as The Cute Woman

Roebuck 'Pops' Staples as Mr. Tucker

Tito Larriva as Ramon

John Ingle as The Preacher

Matthew Posey as The Computer Guy

Swoosie Kurtz as The Lazy Woman

Amy Buffington as Linda Culver

Richard Dowlearn as Larry Culver

Capucine De Wulf as The Little Girl on the Road

Cynthia Gould as Factory Girl #1

Kelly Wright as Factory Girl #2

Hinpheth Siharath as Laotian Factory Worker

Phyllis Wallace as Woman at Plant

Linda McCauley as Louis' Date at Chinese Restaurant

Marian Henley as Moonstone

Huey P. Meaux as Wild Wild Life Club DJ / VJ

Connie Deaton as Lip-Syncher

Jerry Harrison as Lip-Syncher

Meredith Zednick as Lip-Syncher

Alonzo Richard as Lip-Syncher

Chrissy Miller as Lip-Syncher

Tony Reynolds as Lip-Syncher

Eric "E.T." Thorngren as Lip-Syncher

Stephen Seybold as Lip-Syncher

Tina Weymouth as Lip-Syncher

Chris Frantz as Lip-Syncher

Vangie Barefoot as Lip-Syncher

Keith Algier as Lip-Syncher

Freeman Beatty as Lip-Syncher

Ronna Cohen as Air Band

Rex Taylor Smith as Air Band

Scott Valentine as Air Band

James Jackson as Singing Watchman

Angus G. Wynne III as Dancing Businessman

Cora Cardona as Margie Ortiz

Andrew Barach as Laughing Headline Reader #1

Gregory Gunter as Laughing Headline Reader #2

Ric Spiegel as Passerby in Mall

Tom De Nolf as Friend of Passerby

Ed Geldart as Grandfather in Mall

Ray Coahran as Fashion Show Band

Ken Chambers as Fashion Show Band

Daniel Marder as Fashion Show Band

Bale Allen as Teenage Boy in Field

Liz Moore as Teenage Girl in Field

Jim Colegrove as Gospel Band

Tonney Watts as Gospel Band

Vernon Watts as Gospel Band

Frank Smith as Man in Church

L.T. Felty as Duck Hunter

David Averett as Duck Hunter

Evelyn Box as "Hey Now" Kid

Kevin Box as "Hey Now" Kid

Kenan Crinion as "Hey Now" Kid

Jason Liebrecht as "Hey Now" Kid

William McDaniel as "Hey Now" Kid

Brian Monroe as "Hey Now" Kid

Jessica Pendland as "Hey Now" Kid

Michael Pendland as "Hey Now" Kid

John Pritchett as Sound Man

Esteban Jordan as Dance Club Band / Ramon's Band

Christopher Johnson as Mr. Tucker's Son

Louis Black as The Happy Wanderers Strictly Accordion Marching Band (uncredited)

Chris Douridas as Teenage Boy Ventriloquist (uncredited)

Leesa Rowland as Blonde in Nightclub (uncredited)

Randy Erwin as Yodeler