Mahesh Babu as Gautham

Kriti Sanon as Sameera

Nassar as Chandrashekhar's Co-Scientist

Kelly Dorji as Antonio Rosarius

Pradeep Ram Singh Rawat as Taxi Driver

Anand as Chandrashekhar

Anu Hasan as Kalyani

Sayaji Shinde as Inspector John Basha

Posani Krishna Murali as Gulab Singh

Srinivasa Reddy as Police Constable

Ravi Varma as Michael

Surya Bhagawan Das as Gautham's Doctor

Gautham as Gautham (Child Character)

David Corden as Insp. Douglas

Naveen Polishetty as Taxi Driver's Son

Banerjee as Sameera's boss

Sophiya Chaudhary as Special Appearance in 'London Babu' song

Kumud Pant as Car Driver

Paul Blackwell as Police Officer

John Kokken as