Mahesh Babu as Gautham

Kriti Sanon as Sameera

Nassar as Chandrashekhar's Co-Scientist

Anu Hasan as Kalyani

Kelly Dorji as Antonio Rosarius

Sayaji Shinde as Inspector John Basha

Posani Krishna Murali as Gulab Singh

Srinivasa Reddy as Police Constable

Pradeep Ram Singh Rawat as Taxi Driver

Surya Bhagawan Das as Gautham's Doctor

David Corden as Insp. Douglas

Naveen Polishetty as Taxi Driver's Son

John Kokken as

Sophiya Chaudhary as Special Appearance in 'London Babu' song

Gautham as Gautham (Child Character)

Kumud Pant as Car Driver