Jimmy Bennett as Toby Thompson

Jake Short as Nose Noseworthy

Kat Dennings as Stacy Thompson

Trevor Gagnon as Loogie Short

Devon Gearhart as Cole Black

Jolie Vanier as Helvetica Black

Rebel Rodriguez as Lug Short

Leo Howard as Laser Short

Leslie Mann as Mom Thompson

Jon Cryer as Dad Thompson

William H. Macy as Dr. Noseworthy

James Spader as Carbon Black

Angela Lanza as Teacher

Alejandro Rose-Garcia as John / Boyfriend

Cambell Westmoreland as Blinker #1

Zoe Webb as Blinker #2

Chris Orf as Goofy Host

Racer Rodriguez as Bully #1

Rocket Rodriguez as Bully #2

John Chilleri as Hallway Kid (uncredited)

Josh Christman as Classroom Kid (uncredited)

Joshua Drew as Classmate (uncredited)

Zach Irsik as Schoolyard Kid (uncredited)

Ryan Lee as Classmate / Neighborhood Kid (uncredited)

Christina Lehner as Classmate (uncredited)

Micaela Phillips as Girl on Bus (uncredited)

Bella Perryman as Classmate (uncredited)

Cameron R. Murphy as Neighborhood Kid

Henry J. Smith 3rd as Neighborhood Kid (uncredited)

Cameron Wofford as (uncredited)

Alexis Woods as Schoolyard Kid (uncredited)

Tina Rodriguez as Female Employee

Jackson Hurst as Male Employee

Jonathan Breck as Security Guard

Elizabeth Avellan as The Baby (voice)

Bianca Rodriguez as The Baby

Sheilava as Partygoer (uncredited)