Nagarjuna Akkineni as Nageswar Rao / Seetharamudu / Bittu

Nageshwara Rao Akkineni as Chaitanya

Naga Chaitanya Akkineni as Nagarjuna / Radha Mohan

Shriya Saran as Rama Lakshmi / Anjali

Samantha Ruth Prabhu as Krishna Veni / Priya

Brahmanandam as Girish Karnad

Ali Basha as Leonardo DiCaprio

Posani Krishna Murali as Inspector Dharma

Jayaprakash Reddy as Home Minister J.P.

Shankar Melkote as Yashwanth Rayudu

Saranya Ponvannan as Seetharamudu's Mother

Satya Krishnan as Lecturer

Tejaswi Madivada as Divya

M. S. Narayana as Father Francis

Duvvasi Mohan as Home Minister's Assistant

Gundu Sudarshan as Marriage Broker

Saptagiri as Nagarjuna's Friend

Krishnudu as Doctor

Srinivasa Reddy as Car Broker

Chalapathi Rao as Merchant

Amitabh Bachchan as Pratap (Special Appearance)

Amala Akkineni as Dance Teacher (Special Appearance)

Akhil Akkineni as Akhil (Special Appearance)

Neetu Chandra as Air Hostess (Special Appearance)

Raashii Khanna as Prema (Special Appearance)

Lavanya Tripathi as Radha Mohan's Friend (Special Appearance)