Andrew McCarthy as FBI Agent Ben Carroway

Portia de Rossi as Leo Benita

Robert Patrick as Leo Benita

Nick Mancuso as Dr. Samuel Greely

Aaron Lohr as Billy Collins

Lisa Jane Persky as Janice Franklin

Michelle Madden as Anchor Woman

Denise Johnson as Little Girl

Kim Huff as Ben's Mother

Aki Aleong as Dr. Arnold Kuay

Rick Shuster as Helicopter Pilot

Philip Tan as Sensei Assassin

Carl Thibault as Laboratory Guard

Jackie Torres as Esmeralda (uncredited)