Laura San Giacomo as Jenifer Estess

Jane Kaczmarek as Valerie Estess

Annabella Sciorra as Meredith Estess

Jane Alexander as Marilyn Estess

Maddie Corman as Julianne Hoffenberg

Edie Falco as Wheelchair Saleswoman

Donna Hanover as Herself

Camryn Manheim as Nurse Vandemal

Julianna Margulies as Jenifer's Psychiatrist

Rob Morrow as Dr. Richard Feldman

Reed Rudy as Scotty

Cedric Smith as Dr. Richards

Vincent Spano as Jack

Fisher Stevens as Dr. Aaron Sanders

Marisa Tomei as Nina Capelli

Bradley White as Michael

Scott Wolf as Jenifer's Date

Colin Ferguson as Peter

Karen Robinson as Lorna

Jason Blicker as Neurologist

Robert Bockstael as Researcher

Sarah Bolstridge as Jenifer (Age 12)

Christopher Bondy as Jenifer's Father (as Chris Bondy)

Johnie Chase as Bus Driver

David Eisner as Impatient Passenger

Alex Gaistman as Jane (Age 3)

Imogen Haworth as Valerie (Age 14)

Danny Mags as Jake (age 6)

Mallory Margel as Meredith (Age 11)

Jim McAleese as Fire Marshal

Dean Mckenzie as Waiter

Nadia-Leigh Nascimento as Amy

Dave Nichols as Doctor #2

Willis Robbins as Willis

Jason Sharman as (uncredited)