Dennis Quaid as Lt. Tuck Pendleton

Martin Short as Jack Putter

Meg Ryan as Lydia Maxwell

Kevin McCarthy as Victor Eugene Scrimshaw

Fiona Lewis as Dr. Margaret Canker

Vernon Wells as Mr. Igoe

Robert Picardo as The Cowboy

Dick Miller as Cab Driver

Wendy Schaal as Wendy

Harold Sylvester as Pete Blanchard

William Schallert as Dr. Greenbush

Henry Gibson as Mr. Wormwood

John Hora as Ozzie Wexler

Mark L. Taylor as Dr. Niles

Orson Bean as Lydia's Editor

Kevin Hooks as Duane

Kathleen Freeman as Dream Lady

Archie Hahn as Messenger

Kenneth Tobey as Man in Restroom

Joe Flaherty as Waiting Room Patient

Andrea Martin as Waiting Room Patient

Jason Laskay as Scrimshaw's Henchman

Frank Miller as Scrimshaw's Henchman

Christine Avila as Lab Technician

Alexandra Borrie as Lab Technician

Jenny Gago as Lab Technician

Robert Gounley as Lab Technician

Grainger Hines as Rusty

Mike Garibaldi as Cop

Richard McGonagle as Cop

Terence McGovern as Travel Agent

Robert Neches as Lab Guard

Rance Howard as Supermarket Customer

Chuck Jones as Supermarket Customer

Laura Waterbury as Supermarket Customer

Kurt Braunreiter as Lab Assault Henchman

Brewster Sears as Lab Assault Henchman

Alan Blumenfeld as Man with Camera

Jeffrey Boam as Lydia's Interviewee

Sydne Squire as Stewardess

Paul Barselou as Man on Plane

John Miranda as Man in Elevator

Jordan Benjamin as Little Kid in Mall

Roberto Ramirez as Chef

Virginia Boyle as Shopping Lady

Herb Mitchell as Camera Store Clerk

Neil Ross as Pod Computer (voice)

Robert Gray as Lab Assault Henchman

Shawn Nelson as Wendell

Joe Dante as Vectorscope Employee (uncredited)