David Duchovny as Bob Rueland

Minnie Driver as Grace Briggs

Carroll O'Connor as Marty O'Reilly

Robert Loggia as Angelo Pardipillo

Jim Belushi as Joe Dayton

Bonnie Hunt as Megan Dayton

David Alan Grier as Charlie Johnson

Joely Richardson as Elizabeth Rueland

Eddie Jones as Emmett McFadden

Marianne Muellerleile as Sophie

William Bronder as Wally Jatczak

Brian Howe as Mike

Adam Tanguay as Adam Dayton

Karson Pound as Karson Dayton

Chris Barnes as Jeff

Tom Virtue as Dr. Senderak

Dick Cusack as Mr. Bennington

Joseph Gian as Singer

Tamara Tungate as Celia

Jennie Lew Tugend as Paramedic

David Pasquesi as Tony

Don Lake as Transplant Man

Holly Wortell as Marsha

Becky Veduccio as Shari

Darryl Warren as Father Rudy

LaTaunya Bounds as Zebra Girl

Harry Teinowitz as Ice Cream Clerk