Brick Bronsky as Roger Smith

Lisa Gaye as Professor Holt

Leesa Rowland as Victoria

Michael Kurtz as Yoke

Scott Resnick as Dean Okra

Shelby Shepard as Professor Jones

Jackie Moen as Diane / Bald Subhumanoid

Robert Dawson as Murray

Phil Rivo as Harvey / Malathion Man

Erica Frank as Tour Guide

Troy Fromin as Yoke's Sidekick

Paul Borghese as Basketball Coach / Assistant Director

Darla Haun as Plain White Rapper

Alex Pirnie as Mutant Squirrel

William J. Kulzer as Chief Brundt

Madison Monk as Toxic Avenger Director

Suzanne Solari as Squirrels Gang Member

Lisa Star as Squirrels Gang Member

Veronica Stork as Squirrels Gang Member

Mark Richardson as Motorcycle Man / Rock Band - 674IF

Diane C. Skinner as Motorcycle Woman

Trinity Loren as Bald Subhumanoid

Sharon Mitchell as Bald Subhumanoid

Cynthia Windham as Lady who sees 'it's a bird'

Louis Ortiz as Squirrels Gang Member