Maria Callas as Medea

Massimo Girotti as Creonte

Laurent Terzieff as Chirone

Giuseppe Gentile as Giasone

Margareth Clémenti as Glauce

Paul Jabara as Pelias

Gerard Weiss as Second Centaur

Sergio Tramonti as Apsirto, Medea's Brother

Luigi Barbini as Argonaut

Gian Paolo Durgar as

Luigi Masironi as Jason at 5

Michelangelo Masironi as Jason at 13

Gianni Brandizi as Argonaut

Franco Jacobbi as Argonaut

Annamaria Chio as Wet Nurse

Piera Degli Esposti as Woman

Mirella Pamphili as

Graziella Chiarcossi as Glauce's Maid

Rossana Canghiari as Servant of Glauce (uncredited)

Maria Cumani Quasimodo as (uncredited)

Vladimer Julukhadze as (uncredited)

Maria Smith as Maid (uncredited)

Giorgio Trombetti as (uncredited)

Rita Savagnone as Voice Dubbing: Maria Callas / Medea (voice) (uncredited)

Pino Colizzi as Voice Dubbing: Giuseppe Gentile / Jason (voice) (uncredited)

Enrico Maria Salerno as Voice Dubbing: Laurent Terzieff / Centaur (voice) (uncredited)