Chevy Chase as Nick Holloway

Daryl Hannah as Alice Monroe

Sam Neill as David Jenkins

Michael McKean as George Talbot

Stephen Tobolowsky as Warren Singleton

Jim Norton as Dr. Bernard Wachs

Pat Skipper as Morrissey

Paul Perri as Gomez

Richard Epcar as Tyler

Steven Barr as Clellan

Gregory Paul Martin as Richard

Patricia Heaton as Ellen

Barry Kivel as Drunk Businessman

Donald Li as Cab Driver

Rosalind Chao as Cathy DiTolla

Jay Gerber as Roger Whitman

Shay Duffin as Patrick the Bartender

Edmund L. Shaff as Edward Schneiderman

Sam Anderson as Chairman of the House Committee

Elaine Corral Kendall as News Anchor

Ellen Albertini Dow as Mrs. Coulson

Jonathan Wigan as Delivery Boy

I.M. Hobson as Maitre'd

John Carpenter as Helicopter Pilot

Chip Heller as Man Who Hails Taxi

Aaron Lustig as Technician

Tina Kotrich as Tennis Fan (uncredited)