Emma Thompson as Vivian Bearing

Christopher Lloyd as Dr. Harvey Kelekian

Eileen Atkins as Evelyn 'E.M' Ashford

Audra McDonald as Susie Monahan

Jonathan M. Woodward as Dr Jason Posner

Benedict Wong as Fellow 2

Harold Pinter as Mr. Bearing

Raffaello Degruttola as Technician 1

Miquel Brown as Technician 2

Hari Dhillon as Fellow 1

Lachele Carl as Fellow 4

David Menkin as Student 1

Shauna Shim as Student 3

David Zayas as Code Team Blue Head

Jenny Jules as Code Team Blue 5

Gary Beadle as Code Team Blue 6

Rebecca Laurie as Vivian (age 5)