Ben Foster as Lance Armstrong

Chris O'Dowd as David Walsh

Guillaume Canet as Dr. Ferrari

Jesse Plemons as Floyd Landis

Lee Pace as Bill Stapleton

Denis Ménochet as Johan Bruyneel

Edward Hogg as Frankie Andreu

Dustin Hoffman as Bob Hamman

Elaine Cassidy as Betsy Andreu

Laura Donnelly as Emma O'Reilly

Peter Wight as Sunday Times Editor

Nathan Wiley as Charles Pelkey

Chris Larkin as John Wilcockson

Mark Little as Rupert Guinness

Michael G. Wilson as Lance's Doctor

Sid Phoenix as Tony

Josh O'Connor as Rich

Sam Hoare as Stephen Swart

James Harkness as Wayne

Saskia Reeves as Conference Director

Chloe Hayward as Kristin

Adam LeFevre as Jeffrey Tillotson

Brent Langdon as Richard Faulkner

J.D. Evermore as Tailwind Executive

Nicolas Robin as Christophe Bassons

Julien Vialon as John Lelangue

Chiké Okonkwo as Young Hospital Doctor

Daniel Stewart as Sunday Times Lawyer

Yves Aubert as Race Official

Paul Kelleher as Floyd Landis' Father

Philippe Smolikowski as Jean-Michel Rouet

Lucien Guignard as Alberto Contador

John Schwab as Travis Tygart

David Bertrand as U.C.I. Official

Christy Meyer as U.S. Sports Journalist