E. G. Daily as Tommy Pickles (voice)

Nancy Cartwright as Chuckie Finster (voice)

Kath Soucie as Phil DeVille / Lil DeVille (voice)

Cheryl Chase as Angelica Pickles (voice)

Cree Summer as Susie Carmichael (voice)

Dionne Quan as Kimi Finster (voice)

Tara Strong as Dil Pickles (voice)

Pat Musick as Harold Frumpkin / Servant (voice)

Amanda Bynes as Taffy (voice)

Mo'Nique as Aunt Moo (voice)

Rain Pryor as Aunt Moo (Singing) (voice)

Kathy Najimy as Goosey (voice)

Billy Vera as Goldy the Accordion (voice)

Gregg Berger as Ogre / Humpty Dumpty (voice)

Don Lake as Tom Thumb / Gingerbread Man (voice)

Paula Tiso as Henny Penny (voice)

Masasa Moyo as Gospel Singer / Chorus (voice)

Angel Parker as Gospel Singer / Chorus (voice)

Rolonda Watts as Gospel Singer / Chorus (voice)

Carmen Twillie as Chorus (voice)