Lon Chaney as Professor Echo / Granny O'Grady

Mae Busch as Rosie O'Grady

Matt Moore as Hector McDonald

Victor McLaglen as Hercules

Harry Earles as Tweedledee aka Little Willie

Matthew Betz as Detective Regan

Edward Connelly as Judge

William Humphrey as Attorney for Defense

E. Alyn Warren as Prosecuting Attorney

Margie Angus as Twin (uncredited)

Mary Angus as Twin (uncredited)

Walter P. Cole as Human Skeleton (uncredited)

Carrie Daumery as Pet Shop Customer (uncredited)

Delmo Fritz as Sword Swallower (uncredited)

Alice Julian as Fat Lady (uncredited)

Peter Kortes as Sword Swallower (uncredited)

Mickey McBan as Boy Watching Hercules' Act (uncredited)

Wilmuth Merkyl as Jeweler (uncredited)

John Millerta as Wild Borneo Man (uncredited)

Louis Morrison as Police Commissioner (uncredited)

Majorie Morton as Mrs. Arlington (uncredited)

Walter Perry as Dime Museum Announcer (uncredited)

Louis Shank as Newsboy (uncredited)

Vera Vance as Dancer (uncredited)

Charles Wellesley as John Arlington (uncredited)

Percy Williams as Butler (uncredited)