Brendan Fraser as John Crowley

Harrison Ford as Dr. Robert Stonehill

Keri Russell as Aileen Crowley

Courtney B. Vance as Marcus Temple

Meredith Droeger as Megan Crowley

Diego Velazquez as Patrick Crowley

Jared Harris as Docteur Kent Webber

Patrick Bauchau as CEO Erich Loring

Alan Ruck as Pete Sutphen

David Clennon as Dr. Renzler

Dee Wallace as Sal

Ayanna Berkshire as Wendy Temple

P.J. Byrne as Dr. Preston

G.J. Echternkamp as Niles

Vu Pham as Vinh Tran

Derek Webster as Cal Dunning

Jana Lee Hamblin as Renzler Scientist #1

Christopher D. Harder as Researcher

Tra'Renee Chambers as Night Nurse (Marcy)

Lily Mariye as Dr. Waldman

Sherilyn Lawson as Day Nurse (Kate)

Eric Martin Reid as ICU Doctor

Jeanine Jackson as Nell Madden

Robert Blanche as Armed Guard

Michael Shamberg as Renzler Venture Capitalist #1

Sam M. Hall as John Crowley, Jr.

Andrea White as Dr. Allegria

Shelly Lipkin as Senior Scientist

Eric Derovanessian as Security Officer

Patricia Ferguson as Reception Nurse

Jeanette McMahon as Day Nurse (Jane)

Brennan Claire as Julia

Quigley Provost-Landrum as Maria

Kimberly Howard as ICU Nurse

Sharonlee McLean as Stonehill's Secretary

Bryce Flint-Sommerville as Van Driver

Gavin Bristol as Nell Madden

Olga Sanchez as Pediatric Nurse

Chrisse Roccaro as Mega Store Cashier

John Crowley as Renzler Venture Capitalist #2

Christopher Desmond Williams as Security Officer #2

Melanie Sanders as ICU Nurse #2

joe knox as walking man (uncredited)