Matthew Gray Gubler as Raymond

Ray Wise as Donald

Kat Dennings as Becca

Sally Kirkland as Virginia

Jeffrey Combs as Dr. Carpenter

John Waters as Cornelius

Mackenzie Phillips as Mrs. Richards

Barbara Niven as Eve

Muse Watson as Ambrose

Mel Rodriguez as Hector

Ronnie Gene Blevins as Pope

Jack Plotnick as Cousin Freddy

Ray Santiago as Alberto

Shanola Hampton as Ticona

Jessica Camacho as Noelle

Mckenna Grace as Zelda

Hans Howes as Poppy

Jen Soska as Mourner

Sylvia Soska as Mourner

Christopher Mastandrea as Young Raymond