Sam Waterston as Prof. Walter Zarrow

Tim Blake Nelson as Adam Zarrow

Kristen Stewart as Sophie

Glenn Close as Marcia Zarrow

Corey Stoll as Sam

Katie Chang as Amy

Michael Kenneth Williams as Jeffrey

Gretchen Mol as Sarah

Mickey Sumner as Nicole

Jessica Hecht as Jill

David Aaron Baker as Devlin

J. Bernard Calloway as Cedar Lemons

Derrick Baskin as Medical Examiner

Jacqueline Baum as Allie

Ana Marie Calise as Student

Erica Cho as Teacher

Scott Cohen as Dr. Laffer

Philip Ettinger as Roger

K. Todd Freeman as Joe

Ivan Goris as Ignacio

Natasha Gregson Wagner as Marta

Korey Jackson as Actor

Ben Konigsberg as Hal

Hannah Marks as Ella Zarrow

Rob Morgan as Parnell

Julia Morrison as Shani

Cliff Moylan as Bailiff

Annie Parisse as Rachel

Gloria Reuben as Meredith

Casey Roberts as Student

G. Michelle Robinson as Gracie

Erika Rose as Waitress

Nina Rosenthal as Waitress

Ekaterina Samsonov as Angie

Cameron Taylor as Nurse

Yul Vazquez as Dr. Edward Barnes

Lee Wilkof as Ray Eisenberg

Lucas Hedges as Greg

Zenon Zeleniuch as Hospital Visitor

Doris McCarthy as Diner Lady (uncredited)