Dennis Weaver as Dr. Samuel A. Mudd

Susan Sullivan as Frances Mudd

Richard Dysart as Edwin Stanton

Michael McGuire as Capt. Murdock

Nigel Davenport as Colonel George Grenfell

Arthur Hill as General Thomas Ewing

Larry Larson as Riggins Thorpe

Mary Nell Santacroce as Ellen Stanton

Clarence Thomas as Nathaniel

Teddy Milford as Andrew Mudd at Age 6

Angela Tully as Sissy Mudd at Age 4

Ryan Grady as Thomas Mudd at Age 3

Bill Gribble as Tyler / John Wilkes Booth

Luke Halpin as Tyson / David Herrold

Terry Beaver as Union Sergeant

Sean Ahern as 1st Union Soldier

Roy Tatum as Lt. Lovett

Don Kovacs as Officer Lloyd

Lawrence Montaigne as Judge Holt

Harold Bergman as Undersecretary

Fred Covington as Attorney Lake

Joe Dorsey as Gen. Edward Trafe

Jim Peck as Gen. Harris

Greg Oliver as Louis Weichmann

Bill Eudaly as Daniel Thomas

Don Devendorf as George Mudd

Tony Kish as William Watson

Wallace Wilkinson as D.C. Prison Guard

Anthony Edenfield as Escaped Prisoner

Jere Beery as 3rd Guard

Kent Stephens as Zachary

Stuart Culpepper as Boone

Mark Rand as Andrew Mudd at Age 9

Melonie Martin as Sissy Mudd at Age 7

Earl Miller as Thomas Mudd at Age 6

David Hamilton as Sam Jr. at Age 4

Richard Andrew as Dr. Anthony Ellis

Dan Chandler as Master Sergeant

Richard Reiner as 6th Guard

Don Ferguson as 4th Soldier

Jack Norhanian as 5th Guard

Pat Hurley as 1st Patient

Skip Foster as DeCampo

Charles Kaufman as Jones

Tommy Lane as Capt. Longheart

Bill Hindman as President Andrew Johnson

George De Vries as Waters

Ilse Earl as Screaming Woman