Kristen Wiig as Alice Klieg

James Marsden as Rich Ruskin

Linda Cardellini as Gina Selway

Wes Bentley as Gabe Ruskin

Jennifer Jason Leigh as Deb Moseley

Alan Tudyk as Ted Thurber

Tim Robbins as Dr. Daryl Moffet

Joan Cusack as Dawn Hurley

Thomas Mann as Rainer Ybarra

Rose Abdoo as Connie

Shanna Strong as Teenage Alice

Kulap Vilaysack as Grace Dao

Loretta Devine as Barb Vaughn

Joyce Hiller Piven as Miriam Klieg

Jack Wallace as Bud Klieg

Mitch Silpa as Derek

George Basil as Technical Director #2