Hugh Grant as Keith Michaels

Marisa Tomei as Holly Carpenter

Bella Heathcote as Karen Gabney

J.K. Simmons as Dr. Hal Lerner

Chris Elliott as Jim Harper

Allison Janney as Mary Weldon

Caroline Aaron as Ellen

Steven Kaplan as Clem Ronson

Annie Q. Riegel as Sara Liu

Emily Morden as Andrea Stein-Rosen

Aja Naomi King as Rosa

Andrew Keenan-Bolger as Billy Frazier

Maggie Geha as Flo Bai

Nicole Patrick as Jessica

Lauren Macklin as Rachel Anslow

Jason Antoon as Greg Nathan

Frank Harts as Paramedic

Olivia Luccardi as Chloe

Damaris Lewis as Maya

Mark Nelson as Josh

Whit Baldwin as Doug

Vanessa Wasche as Rona

Enid Graham as Trina

Shannon Marie Sullivan as Sue

Jenny Neale as Jenny Glick

Billy Griffith as TSA Agent

Kevin Michael Kennedy as TSA Officer Kevin

Ali Merhi as TSA Agent Ali

Lily Wen as Judy

John Deyle as Fred the Security Guard

Bruce Sabath as Paul Prentiss

Karen Pittman as Naomi Watkins

Veanne Cox as Clara Foss

Kate Cullen Roberts as Tina

Jeff Chena as Carousel Worker

Lauren Palmer as Dana Carpenter

Ella Rubin as Etta Carpenter

Ann S. Lawrence as Customer at Table

Kevin Carolan as Billy's Father

Christina Pawl as Billy's Mother

Liz Callaway as Mrs. Lerner

Sean Patrick McGowan as Holly's Co-Worker

Rebecca Luker as Joan

Sanjiv Jhaveri as Dr. Goel