Matthew Modine as Joe

Catherine Keener as Mary

Daryl Hannah as Kelly

Maxwell Caulfield as Bob

Elizabeth Berkley as Tina

Marlo Thomas as Blair

Bridgette Wilson-Sampras as Sahara

Buck Henry as Dr. Leuter

Christopher Lloyd as Ernst

Kathleen Turner as Dee Dee Taylor

Denis Leary as Doug

Beatrice Winde as Wilma

John Tormey as Harassing Man

Ali Wentworth as Raina

Debra McGrath as Cis

Nahanni Johnstone as Young Woman

Alex Appel as Sheila

Steve Buscemi as Nick

Dave Chappelle as Zee

Landy Cannon as Beach Boy

Katie Griffin as Empty V Interviewer

Missy Yager as Lisa

Karen Woolridge as Nadia

Daniel von Bargen as Devon